Abstract Sirtuins or Sir (Silent information regulator) are NAD+-dependent enzymes playing
an important part in the pathogenesis and treatment of various disorders. They have …

Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …

Silent information regulator two homologue one (SIRT1) is the most widely studied member
of the sirtuin family related to histone deacetylases class III super-family using nicotinamide …

Sirtuins family is a class of NDA+ dependent protein deacetylases that play a key role in the
regulation of several aspects of biological processes, such as cell cycle regulation …

Sirtuins are a family of NAD+-dependent deacetylases (class III histone deacetylases).
Seven mammalian sirtuins, SIRT1-7, are identified, as the functions and locations differ …

Among the sirtuin enzymes, Sirt3 is one of the most important deacetylases as it regulates
acetylation levels in mitochondria, which are linked to the metabolism of multiple organs and …

Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …

As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …

The mitochondrion is an important organelle which participates in many cellular and
physiological functions. It controls mechanisms by converting chemical energy into energy …

Sirt-1 is defined as a nuclear protein involved in the molecular mechanisms of inflammation
and neurodegeneration through the de-acetylation of many different substrates even if …