Reprogramming of cellular energy metabolism is considered an emerging feature of cancer.
Mitochondrial metabolism plays a crucial role in cancer cell proliferation, survival, and …

The lack of substrate-bound crystal structures of SIRT1 and SIRT2 complicates the drug
design for these targets. In this work, we aim to study whether SIRT3 could serve as a target …

Sirtuins (SIRTs) catalyze the NAD+-dependent deacetylation of N ε-acetyl lysines on various
protein substrates. SIRTs are interesting drug targets as they are considered to be related to …

SIRT1 activity is directly coupled with homeostasis and metabolism. SIRT1 is also a
metabolic sensor. It follows that disease-related metabolic abnormalities are likely to …

Sirtuins are members of the Sir2 (silent information regulator 2) family, a group of class III
deacetylases. Mammals have seven different sirtuins, SIRT1–SIRT7. Among them, SIRT1 …

Sirtuins are NAD+ dependent deacetylases and/or ADP-ribosyl transferases active on
histone and non-histone substrates. The first sirtuin was discovered as a transcriptional …

The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs)
which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this …

Liver disease has become one of the main causes of health issue worldwide. Sirtuin (Sirt) 2
is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, and is expressed in …

Introduction: Dysregulation of metabolic pathways, caused by imbalances in energy
homeostasis, leads to type 2 diabetes characterized by high glucose concentration in the …

Sirtuin 2 (SIRT2) is a member of the sirtuin protein family. It is a Class III histone deacetylase
(HDACs) and predominantly localized to the cytosol. SIRT2 deacetylates histones and a …