The renal actions of parathyroid hormone (PTH) promote 1, 25-vitamin D generation;
however, the signaling mechanisms that control PTH-dependent vitamin D activation remain …

Vitamin D metabolism centers on kidney regulation of Cyp27b1 by mineralotropic hormones,
including induction by parathyroid hormone (PTH), suppression by fibroblast growth factor …

Cyp27b1 and Cyp24a1 are reciprocally regulated in the kidney by the key hormones PTH,
FGF23, and 1, 25 (OH) 2 D 3. Our recent genomic studies in mice identified a complex …

Chronic Kidney Disease (CKD), a disorder that affects 11% of the world's population, is
characterized by an acceleration in skeletal, immune, renal, and cardiovascular aging that …

In hypocalcaemia, elevated parathyroid hormone transitorily down-regulates the kidney
vitamin D receptor, which returns to normal levels with the rise in serum extracellular calcium …

The differential effects between cinacalcet and active vitamin D compounds on parathyroid
function, mineral metabolism, and skeletal function are incompletely understood. Here, we …

Calcitriol, a powerful regulator of phosphate metabolism and immune response, is
generated by 25-hydroxyvitamin D 1α-hydroxylase in the kidney and macrophages. Renal …

Impaired mineral homeostasis and inflammation are hallmarks of chronic kidney disease
(CKD), yet the underlying mechanisms of electrolyte regulation during CKD are still unclear …

A common consequence of chronic renal disease is secondary hyperparathyroidism (SHPT)
and is closely related to the mortality and morbidity of uremia patients. Secondary …

The cytochrome P450 enzyme 24-hydroxylase (CYP24) plays a critical role in regulating
levels of vitamin D hormone. Aberrant expression of CYP24 has been implicated in vitamin …