Abstract Phosphatidylinositol 3-kinases (PI3K)/AKT/mammalian target of rapamycin (mTOR)
pathway plays a crucial role in integrating a variety of extracellular stimuli to regulate growth …

Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Inappropriate PI3K signaling is one of the most frequent occurrences in human cancer and
is critical for tumor progression. A variety of genetic mutations and amplifications have been …

Abstract The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated
pathways in cancer and, consequently, more than 40 compounds that target key …

PI3K/AKT/mTOR pathway is an established oncogenic driver in humans. Targeted biologic
agents against components of this pathway have shown promising activity leading to the …

ABSTRACT Introduction: The phosphatidylinositol 3-kinase/protein kinase-B/mammalian
target of rapamycin (PI3K/AKT/mTOR) pathway is a fundamental regulator of cell …

The mammalian target of rapamycin (mTOR) and the phosphoinositide 3-kinase (PI3K)
signaling pathways are commonly deregulated in cancers and promote cellular growth …

Abstract The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR)
signaling pathway regulates proliferation, survival and metabolism, and its dysregulation is …

Molecular targeted agents have enlarged the armamentarium of anti-cancer therapies.
Along with the success of some anti-growth factor receptors, signal transduction inhibitors …