The aim of this work was to investigate the role of mucoadhesion in the insulin uptake of
nanocomplexes (NC) based of trimethyl chitosan (TMC) and poly (ethylene glycol)(PEG) …

Trimethyl chitosan-cysteine conjugate (TMC-Cys) was synthesized in an attempt to combine
the mucoadhesion and the permeation enhancing effects of TMC and thiolated polymers …

Purpose The effect of chitosan and polyethylene glycol (PEG) ylated trimethyl chitosan
copolymer structure on the uptake and transport of insulin nanocomplexes was evaluated …

Objectives The objective of this work was to explore the potential and safety of trimethyl
chitosan (TMC) and PEGylated TMC for improved absorption of insulin after nasal …

In this study, insulin-loaded nanoparticles (NPs) were prepared via self-gelation method
using chitosan and aqueous soluble snail mucin as natural polymers. Herein, mucins were …

Oral administration of protein drugs is greatly impeded by the lack of drug carriers that can
efficiently overcome the absorption barriers of mucosa tissue, which consists of not only …

The present investigation explores an oral insulin delivery system based on the modification
of chitosan, N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan (HTCC). Synthesis of …

It is desirable to design nanoparticles for oral insulin delivery that can cross mucus layer and
epithelial membrane in the intestine in the meantime. Thus, using chitosan (CS) as the …

The aim of this paper was to evaluate the penetration enhancement properties of
nanoparticles (NP) based on N-trimethyl chitosan (TMC 35% quaternization degree) loaded …

There are many ongoing investigations to improve the oral bioavailability of peptide and
protein formulations. Bioadhesive polysaccharide chitosan nanoparticles (CS-NPs) would …