In recent years, the development of powerful viral gene transfer techniques has greatly
facilitated the study of gene function. This review summarises some of the viral delivery …

Viral vectors are becoming increasingly important tools to investigate the function of neural
proteins and to explore the feasibility of gene therapy to treat diseases of the nervous …

Our ability to manipulate the genetic constitution of the nervous system has come of age with
various technologies, including virus vectors that can efficiently deliver genes to neurons …

Gene transfer into the brain allows the manipulation of transgene expression in both time
and space. Recently developed gene transfer technologies allow transgenes to be …

Viruses are intracellular parasites with simple DNA or RNA genomes. Virus life revolves
around three steps: infection of a host cell, replication of its genome within the host cell …

No matter what their origin, strain and family, viruses have evolved exquisite strategies to
reach and penetrate specific target cells where they hijack the cellular machinery to express …

Although most research in the field of somatic gene therapy has investigated the use of
recombinant viruses for transferring genes into somatic target cells, various methods for …

The use of viruses to transduce genes of interest into mammalian cells has been extremely
revolutionary, both in terms of laboratory research and for clinical purposes. This approach …

The efficient delivery of therapeutic genes and appropriate gene expression are the crucial
issues for clinically relevant gene therapy. Viruses are naturally evolved vehicles which …

Genetic manipulation of the adult mammalian nervous system is one of the most exciting
areas in contemporary neurobiology. The explosive growth of this field has been facilitated …