Over the last three decades, interest in the field of gene therapy seems to have fluctuated
between hot and cold. Encouraging pre-clinical and clinical data has demonstrated the …

A fundamental problem in neuroscience has been the creation of suitable in vivo model
systems to study basic neurological phenomena and pathology of the central nervous …

Gene transfer is an increasingly utilized approach for research and clinical applications
involving the central nervous system (CNS). Vectors for gene transfer can be as simple as …

One of the greatest challenges to gene therapy is the targetting of gene delivery selectively
to the sites of disease and regulation of transgene expression without adverse effects …

The use of viral vectors as gene transfer tools for the central nervous system has seen a
significant growth in the last decade. Improvements in the safety, efficiency and specificity of …

Viral vector is the most effective means of gene transfer to modify specific cell type or tissue
and can be manipulated to express therapeutic genes. Several virus types are currently …

importantly, in nondividing cells, a single administration based vectors designed to control
the of Ad-or HSV-1-based vectors results in transgene cellular fate of delivered genes …

Publisher Summary The achievement of robust and regulated protein production in
mammalian cells is a complex process that requires careful consideration of many factors …

To achieve therapeutic success, transfer vehicles for gene therapy must be capable of
transducing target cells while avoiding impact on non-target cells. Despite the high …

Gene therapy is “á la mode” and extends well beyond its own research fields, as is
evidenced by special issues of multidisciplinary journals and frequent headlines in the …