HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV-1/HAART-associated lipodystrophy

M Giralt, P Domingo, JP Guallar… - Antiviral …, 2006 - journals.sagepub.com
Background The aetiopathogenic bases of HIV-1-/highly active antiretroviral treatment
(HAART)-associated lipodystrophy (HALS) are poorly known, but this syndrome indicates …

Differentially altered molecular signature of visceral adipose tissue in HIV-1–associated lipodystrophy

JM Gallego-Escuredo, J Villarroya… - JAIDS Journal of …, 2013 - journals.lww.com
Objective: Lipodystrophy in HIV-1–infected antiretroviral-treated patients is often associated
with opposite alterations in adipose tissue depots as follows: lipoatrophy of subcutaneous …

Visceral fat as target of highly active antiretroviral therapy-associated metabolic syndrome

G Barbaro - Current pharmaceutical design, 2007 - ingentaconnect.com
HIV-associated lipodystrophy or lipoatrophy, unreported before the introduction of highly
active antiretroviral therapy (HAART), was first described in 1998, and has a prevalence …

Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity

F Villarroya, P Domingo, M Giralt - Trends in pharmacological sciences, 2005 - cell.com
The lipodystrophy syndrome and associated metabolic alterations are the most prevalent
adverse effects in HIV-infected patients taking highly active anti-retroviral therapy (HAART) …

Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in …

K Kannisto, J Sutinen, E Korsheninnikova, RM Fisher… - Aids, 2003 - journals.lww.com
Objective: To determine the expressions of multiple genes in the subcutaneous adipose
tissue of HIV-positive, highly active antiretroviral therapy (HAART)-treated patients with and …

Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy

J Sutinen, AM Häkkinen, J Westerbacka… - Aids, 2002 - journals.lww.com
Objective: To determine liver fat content in patients with highly active antiretroviral therapy
(HAART)-associated lipodystrophy. Background: Lipodystrophy in several animal models is …

Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy

PDP Domingo, V Estrada, J López-Aldeguer… - … , vol. 14, num. 2, p. 112 …, 2012 - diposit.ub.edu
More than 15 years after the introduction of highly active antiretroviral therapy, HIV/HAART-
associated lipodystrophy syndrome still shadows the indisputable efficacy of antiretroviral …

Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy

CM Shikuma, N Hu, C Milne, F Yost, C Waslien… - Aids, 2001 - journals.lww.com
Objective To determine whether the peripheral fat wasting (lipodystrophy), which is seen in
association with highly active antiretroviral therapy (HAART) that includes a nucleoside …

Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic …

V Jan, P Cervera, M Maachi, M Baudrimont… - Antiviral …, 2004 - journals.sagepub.com
Objective To achieve a better understand of the pathophysiology of HIV-related lipoatrophy,
we compared the mRNA expression of adipocytokines in fat samples from patients and …

Mitochondrial damage in adipose tissue of untreated HIV-infected patients

G Garrabou, S Lopez, C Morén, E Martínez… - Aids, 2011 - journals.lww.com
Objective: Antiretrovirals, especially thymidine-analogue nucleoside reverse transcriptase
inhibitors (tNRTIs), may cause the mitochondrial damage in adipose tissue that has been …