The ubiquitin-proteasome system plays an important role in spermatogenesis. However, the
functions of deubiquitinating enzymes in this process remain poorly characterized. We …

The ubiquitin-proteasome system (UPS) controls intracellular protein turnover in a substrate-
specific manner via E3-type ubiquitin ligases. Mammalian fertilization and particularly sperm …

The ubiquitin proteasome system (UPS) participates in many biological processes ranging
from cell cycle and antigen processing to cellular defense and signaling. Work of the last …

Protein ubiquitination is a stable, covalent post‐translational modification that alters protein
activity and/or targets proteins for proteolysis by the 26S proteasome. The E1‐type ubiquitin …

Spermatozoa are unique cells that have highly compact DNA, motility (and hypermotility)
patterns, a specific morphology, localized mitochondria and an apical acrosome. They are …

Four proteasome subtypes are commonly present in mammalian tissues: standard
proteasomes, which contain the standard catalytic subunits β1, β2 and β5; …

Background The process of fertilization involves a cell fusion event between the sperm and
oocyte. Although sperm contain mitochondria when they fuse with the oocyte, paternal …

Spermatogenesis consists of a series of highly regulated processes that include mitotic
proliferation, meiosis and cellular remodeling. Although alterations in gene expression are …

Ubiquitin and ubiquitin‐like proteins control the degradation of substrates as diverse as
cyclins, viral envelope proteins, plasma membrane receptors, and mRNAs. The …

Background Male-factor infertility presents a vexing problem for many reproductively active
couples. Many studies have focused on abnormal sperm parameters. Recent advances in …