Meiosis, which produces haploid progeny, is critical to ensuring both faithful genome
transmission and genetic diversity. Proteasomes play critical roles at various stages of …

Spermatogenesis is the process by which terminally differentiated sperm are produced from
male germline stem cells. This complex developmental process requires the coordination of …

Male infertility accounts for half of the infertility problems experienced by couples.
Azoospermia, having no measurable level of sperm in seminal fluid, is one of the known …

The ubiquitin-proteasome pathway has been implicated in the penetration of ascidian
vitelline envelope by the fertilizing spermatozoon (Sawada et al., Proc Natl Acad Sci USA …

Proteomic profiling of the mouse spermatozoon has generated a unique and valuable
inventory of candidates that can be mined for potential contraceptive targets and to further …

Up to 30% of men with normal semen parameters suffer from infertility and the reason for this
is unknown. Altered expression of sperm proteins may be a major cause of infertility in these …

Background Although male factor accounts for 40%–50% of unintended childlessness, we
are far from fully understanding the detailed causes. Usually, affected men cannot even be …

Protein ubiquitin‐proteasome (ubiquitin‐proteasome) system is the major mechanism
responsible for protein degradation in eukaryotic cell. During spermatogenesis, the …

The highly complex and species‐selective mechanism of fertilization is a central theme of
developmental biology. Gametogenesis, sperm activation, and egg–sperm recognition are …

The normal structure and function of sperm are prerequisites for successful fertilization and
embryonic development, but little is known about how defective sperm are eliminated during …