Bacteria predominantly exist as multicellular aggregates known as biofilms that are
associated with at least two thirds of all infections and exhibit increased adaptive resistance …

Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

The increasing onset of multidrug-resistant bacteria has propelled microbiology research
towards antimicrobial peptides as new possible antibiotics from natural sources …

Health leaders and scientists worldwide consider antibiotic resistance among the world's
most dangerous pathogens as one of the biggest threats to global health. Antibiotic …

Small cationic, amphipathic peptides with critical roles in host defenses often exhibit
overlapping but distinct immunomodulatory activity, direct antimicrobial activity towards …

Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-
threatening infections in humans. At least two-thirds of all clinical infections are biofilm …

The treatment of bacterial diseases is facing twin threats, with increasing bacterial antibiotic
resistance and relatively few novel compounds or strategies under development or entering …

Bacterial biofilms pose a major threat to public health, as they are associated with at least
two thirds of all infections. They are highly resilient and render conventional antibiotics …

Highlights•To date no antibiotics have been specifically developed for biofilm infections.•Anti-
biofilm peptides directly address chronic multi-resistant bacterial infections.•They …

In many infections, bacteria form surface-associated communities known as biofilms that are
substantially more resistant to antibiotics than their planktonic counterparts. Based on the …