Leukocytes possess the ability to migrate upstream—against the direction of flow—on
surfaces of specific chemistry. Upstream migration was first characterized in vitro for T-cells …

T-lymphocyte migration is important for homing, cell trafficking, and immune surveillance. T-
lymphocytes express lymphocyte function-associated antigen-1 (LFA-1; αLβ2) and very late …

The recruitment of immune cells during inflammation is regulated by a multi-step cascade of
cell rolling, activation, adhesion and transmigration through the endothelial barrier. Similarly …

Cells migrate by applying rearward forces against extracellular media. It is unclear how this
is achieved in amoeboid migration, which lacks adhesions typical of lamellipodia-driven …

In order to perform critical immune functions at sites of inflammation, circulatory T
lymphocytes must be able to arrest, adhere, migrate and transmigrate on the endothelial …

Leukocyte migration across endothelial cell borders (paracellular) and through endothelial
cells (transcellular) appear to be distinct processes. During paracellular migration …

Neither the innate nor adaptive immune system “responds” unless leukocytes cross blood
vessels. This process occurs through diapedesis, in which the leukocyte moves in an …

Leukocyte transmigration occurs at specific locations (portals) on the endothelium, but the
nature of these portals is not clear. Using intravital confocal microscopy of anesthetized …

Leukocytes attach to vascular endothelial cells at the site of inflammation via a series of
intercellular adhesive interactions. In a separate step in leukocyte extravasation …

The leukocyte adhesion cascade is of critical importance for both the maintenance of
immune homeostasis and the ability of immune cells to perform effector functions. Here, we …