Infertility is a major reproductive health problem affecting 10% to 15% of couples, with
approximately equal contributions. Spermatogenesis is a dynamic and multistep process of …

Infertility is a major health problem today, affecting about 15% of couples trying to conceive a
child. Impaired fertility of the male factor is causative in 20% of infertile couples and …

OBJECTIVE: To illustrate the necessity for an enhanced understanding of the genetic basis
of male factor infertility, to present a comprehensive synopsis of these genetic elements, and …

BACKGROUND In spite of tremendous efforts by a number of groups, the search for single
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …

Infertility is one of the most serious social problems facing advanced nations. In general,
approximate half of all cases of infertility are caused by factors related to the male partner …

BACKGROUND Human male infertility has a notable genetic component, including well-
established diagnoses such as Klinefelter syndrome, Y-chromosome microdeletions and …

Genetic causes can be directly responsible for various clinical conditions of male infertility
and spermatogenic impairment. With the increased use of assisted reproduction …

Genetic causes account for 10–15% of severe male infertility, including chromosomal
aberrations and single gene mutations. Natural selection prevents the transmission of …

Despite the fact that hundreds of genes are known to affect fertility in animal models,
relatively little is known about genes that influence natural fertility in humans. To broadly …

Objectives To identify the role of next-generation sequencing (NGS) in male infertility, as
advances in NGS technologies have contributed to the identification of novel genes …