Combining genotypes and T cell receptor distributions to infer genetic loci determining V (D) J recombination probabilities
Every T cell receptor (TCR) repertoire is shaped by a complex probabilistic tangle of
genetically determined biases and immune exposures. T cells combine a random V (D) J …
genetically determined biases and immune exposures. T cells combine a random V (D) J …
[HTML][HTML] Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells
The adaptive immune system's capability to protect the body requires a highly diverse
lymphocyte antigen receptor repertoire. However, the influence of individual genetic and …
lymphocyte antigen receptor repertoire. However, the influence of individual genetic and …
Predicting the spectrum of TCR repertoire sharing with a data‐driven model of recombination
Despite the extreme diversity of T‐cell repertoires, many identical T‐cell receptor (TCR)
sequences are found in a large number of individual mice and humans. These widely …
sequences are found in a large number of individual mice and humans. These widely …
[HTML][HTML] Somatic variation of T-cell receptor genes strongly associate with HLA class restriction
PL Klarenbeek, ME Doorenspleet, REE Esveldt… - PLoS …, 2015 - journals.plos.org
Every person carries a vast repertoire of CD4+ T-helper cells and CD8+ cytotoxic T cells for
a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell …
a healthy immune system. Somatic VDJ recombination at genomic loci that encode the T-cell …
Human T cell receptor occurrence patterns encode immune history, genetic background, and receptor specificity
WS DeWitt III, A Smith, G Schoch, JA Hansen… - Elife, 2018 - elifesciences.org
The T cell receptor (TCR) repertoire encodes immune exposure history through the dynamic
formation of immunological memory. Statistical analysis of repertoire sequencing data has …
formation of immunological memory. Statistical analysis of repertoire sequencing data has …
huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level
L Wu, Z Xue, S Jin, J Zhang, Y Guo, Y Bai… - Nucleic Acids …, 2022 - academic.oup.com
T-cell receptors (TCRs) and B-cell receptors (BCRs) are critical in recognizing antigens and
activating the adaptive immune response. Stochastic V (D) J recombination generates …
activating the adaptive immune response. Stochastic V (D) J recombination generates …
Chromatin conformation governs T-cell receptor Jβ gene segment usage
T cells play fundamental roles in adaptive immunity, relying on a diverse repertoire of T-cell
receptor (TCR) α and β chains. Diversity of the TCR β chain is generated in part by a random …
receptor (TCR) α and β chains. Diversity of the TCR β chain is generated in part by a random …
[HTML][HTML] IMPre: an accurate and efficient software for prediction of T-and B-cell receptor germline genes and alleles from rearranged repertoire data
W Zhang, IM Wang, C Wang, L Lin, X Chai… - Frontiers in …, 2016 - frontiersin.org
Large-scale study of the properties of T-cell receptor (TCR) and B-cell receptor (BCR)
repertoires through next-generation sequencing is providing excellent insights into the …
repertoires through next-generation sequencing is providing excellent insights into the …
[PDF][PDF] Two mutually exclusive local chromatin states drive efficient V (D) J recombination
Summary Variable (V), diversity (D), and joining (J)(V (D) J) recombination is the first
determinant of antigen receptor diversity. Understanding how recombination is regulated …
determinant of antigen receptor diversity. Understanding how recombination is regulated …
Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing
T-cell receptor (TCR) genomic loci undergo somatic V (D) J recombination, plus the
addition/subtraction of nontemplated bases at recombination junctions, in order to generate …
addition/subtraction of nontemplated bases at recombination junctions, in order to generate …