Organism survival depends on oxygen delivery and utilization to maintain the balance of
energy and toxic oxidants production. This regulation is crucial to the brain, especially after …

Before energy metabolism can take place, brain cells must be supplied with oxygen and
glucose. Only then, in combination with normal mitochondrial function, sufficient energy …

Oxygen is crucial for aerobic cellular metabolism; however, mitochondrial respiration can
also form reactive oxygen species (ROS)[1], the level of which directly correlates with …

Shock is a systemic form of acute circulatory failure leading to cellular dysoxia and death.
Such a state of aerobic metabolism failure also underlies neuronal cell death in severe …

To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential.
Cerebral tissue oxygenation represents the balance between oxygen supply and …

Cerebrovascular disease and trauma are leading causes of death in the United States. In
addition to the initial insult to the brain, disturbances of cerebral oxygenation and …

Background: Ischemic and hypoxic secondary brain insults are common and detrimental in
traumatic brain injury (TBI). Treatment aims to maintain an adequate cerebral blood flow with …

Although there is growing interest in the use of brain tissue oxygenation as a resuscitative
endpoint, many of these therapies are based on physiologic principles with little robust …

Cerebral ischemia is a well-recognized contributor to high morbidity and mortality after
traumatic brain injury (TBI). Standard of care treatment aims to maintain a sufficient oxygen …

Background Hypoxia is a common occurrence following stroke and associated with poor
clinical and functional outcomes. Normal oxygen physiology is a finely controlled …