Brain oxygen optimization in severe traumatic brain injury phase-II: a phase II randomized trial

DO Okonkwo, LA Shutter, C Moore… - Critical care …, 2017 - journals.lww.com
Objectives: A relationship between reduced brain tissue oxygenation and poor outcome
following severe traumatic brain injury has been reported in observational studies. We …

Brain oxygenation and energy metabolism: part I—biological function and pathophysiology

A Zauner, WP Daugherty, MR Bullock, DS Warner - Neurosurgery, 2002 - journals.lww.com
Abstract CONTINUOUS OXYGEN DELIVERY and CO 2 clearance are paramount in the
maintenance of normal brain function and tissue integrity. Under normal conditions, aerobic …

The Neuroprotection Effect of Oxygen Therapy: A Systematic Review and Meta‑analysis

Z Deng, W Chen, J Jin, J Zhao - Nigerian Journal of Clinical Practice, 2018 - ajol.info
This study reviews the oxygen therapy (normobaric oxygen [NBO] and hyperbaric oxygen
[HBO]) in both stroke and traumatic brain injury (TBI) patients and meta‑analyzes the efficacy …

[HTML][HTML] Monitoring cerebral oxygenation in acute brain-injured patients

C Robba, FS Taccone, G Citerio - Intensive care medicine, 2022 - Springer
Monitoring cerebral oxygenation may improve the understanding of brain dysfunction after
an acute brain injury (ABI)[1]. Indeed, ABI leads to a cascade of events resulting in altered …

Titrating the dose of oxygen after severe traumatic brain injury in the era of precision medicine

PM Kochanek, H Bayır - Journal of Neurotrauma, 2017 - liebertpub.com
Over the past 40 to 50 years, we have made strides in understanding the molecular
underpinnings of oxidative stress and its consequences in severe traumatic brain injury …

[HTML][HTML] Advanced cerebral monitoring in neurocritical care

N Barazangi, JC Hemphill - Neurology India, 2008 - journals.lww.com
New cerebral monitoring techniques allow direct measurement of brain oxygenation and
metabolism. Investigation using these new tools has provided additional insight into the …

Heterogeneity of Brain Oxidative Metabolism and Hypoxia Response: Mammalian Systems and Nature's Solutions

JF Dunn, ES Rhodes, T Panz - Oxygen Transport to Tissue XIX, 1997 - Springer
Brain ischemia (defined here as restricted flow) and/or hypoxia (defined here as a reduced
oxygen supply) caused by stroke is a major cause of death and debilitation. In addition …

In Silico Model of Critical Cerebral Oxygenation after Traumatic Brain Injury: Implications for Rescuing Hypoxic Tissue

K Kohler, S Nallapareddy, A Ercole - Journal of Neurotrauma, 2019 - liebertpub.com
Cerebral oxygen delivery is central to the modern intensive care of patients with severe
traumatic brain injury. Low brain tissue oxygen tension (PbtO2) results from microvascular …

Brain oxygen tension in severe head injury

WA Van den Brink, H van Santbrink… - …, 2000 - journals.lww.com
OBJECTIVE: Ensuring adequate cerebral oxygenation and perfusion is of fundamental
importance in the treatment of patients with acute cerebral disorders. Online continuous …

Association between early hyperoxia and worse outcomes after traumatic brain injury

M Brenner, D Stein, P Hu, J Kufera, M Wooford… - Archives of …, 2012 - jamanetwork.com
Objective To investigate the relationship between oxygenation and short-term outcomes in
patients with traumatic brain injury (TBI). Design Logistic regression analysis was used to …