Introduction Management of traumatic brain injury (TBI) includes invasive monitoring to
prevent secondary brain injuries. Intracranial pressure (ICP) monitor is the main …

Background During the prior decade, human and animal studies have demonstrated an
association between cerebral hypoxia and poor outcome. These studies have helped to …

Traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) are critical neurological
conditions that necessitate specialized care in the Intensive Care Unit (ICU). Managing …

Objective: To determine whether hyperventilation exacerbates cerebral ischemia and
compromises oxygen metabolism (CMRO 2) following closed head injury. Design: A …

Background Evidence regarding the relationship between in-hospital mortality and SpO2
was low oxygen saturations are often thought to be harmful, new research in patients with …

BACKGROUND: Utilization of brain tissue oxygenation (pBtO 2) is an important but
controversial variable in the treatment of traumatic brain injury. We hypothesize that pBtO 2 …

Background Monitoring the injured brain is an integral part of the management of severely
brain injured patients in intensive care. There is increasing interest in methods to monitor …

Brain injury results from ischemia, tissue hypoxia, and a cascade of secondary events. The
cornerstone of neurocritical care management is optimization and maintenance of cerebral …

Ischemia-Reperfusion (IR) injury is known to contribute significantly to the morbidity and
mortality associated with ischemic strokes. Ischemic cerebrovascular accidents account for …

Background: Brain tissue oxygenation (PbtO 2)-guided management facilitates treatment of
reduced PbtO 2 episodes potentially conferring survival and outcome advantages in severe …