Abstract Background/Aims: This study investigated the relation of midlife blood pressure,
total cholesterol, body mass index (BMI), their changes over time, apolipoprotein E, and …

Background Diffusion tensor imaging measures of white matter (WM) microstructural
integrity appear to provide earlier indication of WM injury than WM hyperintensities; …

Background and Purpose—MRI scans of the brains of elderly people frequently show white
matter lesions. Clinically, these lesions are associated with cognitive impairment and …

Background—Blood pressure (BP) is recognized as a major risk factor for white matter
lesions (WMLs), but longitudinal data are scarce, and there is insufficient evidence for the …

Several potential vascular risk factors exist for the development and accumulation of
subcortical white matter disease in older people. We have reported that in older people …

Background: We investigated the longitudinal relationship between body mass index (BMI),
a major vascular risk factor, and white matter lesions (WMLs) in older women. Methods …

Cerebrovascular disease plays an important role in cognitive disorders in the elderly.
Cerebrovascular disease and Alzheimer's disease interact on several levels, with one …

There is growing evidence that midlife risk factors for vascular disease also are risk factors
for dementia, but there is still need for long-term observational studies to address this. Our …

High blood pressure is considered an important risk factor for cerebral white matter lesions
(WMLs) in the aging population. In a longitudinal population-based study of 665 …

Cerebrovascular disease is an independent risk factor for dementia that may also be
synergistic with Alzheimer's disease. In recent years attention has switched from cerebral …