Multi-drug resistant (MDR) bacteria are an increasingly serious threat to global public health.
In the last decades, many studies showed that general outer membrane porins (OMPs) from …

Gram-negative bacteria pose a serious public health concern, primarily due to a higher
frequency of antibiotic resistance conferred to them as a result of low permeability of their …

Understanding molecular properties of outer membrane channels of Gram-negative bacteria
is of fundamental significance as they are the entry point of polar antibiotics into bacteria …

Gram-negative bacteria pose a serious public health concern due to resistance to many
antibiotics, caused by the low permeability of their outer membrane (OM). Effective …

The emergence of Gram‐negative “superbugs” exhibiting resistance to known antibacterials
poses a major public health concern. Low molecular weight Gram‐negative antibacterials …

The global emergence of antibiotic resistance, especially in Gram-negative bacteria, is an
urgent threat to public health. Discovery of novel classes of antibiotics with activity against …

One of the main fundamental mechanisms of antibiotic resistance in Gram-negative bacteria
comprises an effective change in the membrane permeability to antibiotics. The Gram …

Antibiotic resistance continues to pose a major challenge in the treatment of bacterial
infections. Gram-negative bacteria are particularly troublesome as antibiotics face additional …

Outer membrane protein F (OmpF) is a nonspecific, water-filled channel that allows the
passage of hydrophilic antibiotics across the lipid barrier of Gram-negative bacteria. The …

Gram-negative bacteria are protected by an outer membrane barrier, and to reach their
periplasmic target, penicillins have to diffuse through outer membrane porins such as OmpF …