Galanin, galanin receptors, and drug targets
K Mitsukawa, X Lu, T Bartfai - Galanin, 2010 - Springer
Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems
and in the endocrine system, has been shown to regulate numerous physiological and …
and in the endocrine system, has been shown to regulate numerous physiological and …
Targeted disruption of galanin: new insights from knock-out studies
D Wynick, A Bacon - Neuropeptides, 2002 - Elsevier
The neuropeptide galanin has a widespread but no means ubiquitous expression pattern in
the nervous and endocrine systems. Profound changes in the levels and distribution of the …
the nervous and endocrine systems. Profound changes in the levels and distribution of the …
Galanin peptide levels in hippocampus and cortex of galanin-overexpressing transgenic mice evaluated for cognitive performance
Galanin-overexpressing transgenic mice (GAL-tg) generated on a dopamine β-hydroxylase
promoter were previously shown to express high levels of galanin mRNA in the locus …
promoter were previously shown to express high levels of galanin mRNA in the locus …
An assembly of galanin–galanin receptor signaling network
L Gopalakrishnan, O Chatterjee, C Raj… - Journal of Cell …, 2021 - Springer
The galanin receptor family of proteins is present throughout the central nervous system and
endocrine system. It comprises of three subtypes—GalR1, GalR2, and GalR3; all of which …
endocrine system. It comprises of three subtypes—GalR1, GalR2, and GalR3; all of which …
Galanin inhibits acetylcholine release from rat cerebral cortex via a pertussis toxin-sensitive Giprotein
HY Wang, KD Wild, RP Shank, DHS Lee - Neuropeptides, 1999 - Elsevier
Galanin has been implicated in various physiological functions including memory, feeding
and pain perception. Using rat cerebral cortical slices and synaptosome preparations …
and pain perception. Using rat cerebral cortical slices and synaptosome preparations …
In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures
AM Mazarati, RA Baldwin, S Shinmei… - Journal of …, 2005 - Wiley Online Library
The neuropeptide galanin suppresses seizure activity in the hippocampus by inhibiting
glutamatergic neurotransmission. Galanin may also modulate limbic seizures through …
glutamatergic neurotransmission. Galanin may also modulate limbic seizures through …
Galanin in Ascending Systems: Focus on Coexistence with 5‐Hydroxytryptamine and Noradrenaline a
Galanin can be synthesized in several ascending systems including cholinergic forebrain
neurons, serotonergic dorsal raphe neurons, and the noradrenergic locus coeruleus system …
neurons, serotonergic dorsal raphe neurons, and the noradrenergic locus coeruleus system …
Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference
NM Neugebauer, RM Henehan, CA Hales… - Pharmacology …, 2011 - Elsevier
Previous work has indicated that the neuropeptide galanin decreases sensitivity to the
rewarding effects of morphine and cocaine, but increases alcohol drinking. The aim of the …
rewarding effects of morphine and cocaine, but increases alcohol drinking. The aim of the …
A role for galanin N-terminal fragment (1–15) in anxiety-and depression-related behaviors in rats
C Millón, A Flores-Burgess, M Narváez… - International Journal …, 2015 - academic.oup.com
Background: Galanin (GAL) plays a role in mood regulation. In this study we analyzed the
action of the active N-terminal fragment [GAL (1–15)] in anxiety-and depression-related …
action of the active N-terminal fragment [GAL (1–15)] in anxiety-and depression-related …
Differential galanin receptor‐1 and galanin expression by 5‐HT neurons in dorsal raphé nucleus of rat and mouse: evidence for species‐dependent modulation of …
JA Larm, PJ Shen, AL Gundlach - European Journal of …, 2003 - Wiley Online Library
Galanin and galanin receptors are widely expressed by neurons in rat brain that either
synthesize/release and/or are responsive to, classical transmitters such as γ‐aminobutyric …
synthesize/release and/or are responsive to, classical transmitters such as γ‐aminobutyric …