Physical stimulation of airway surfaces evokes liquid secretion, but the events that mediate
this vital protective function are not understood. When cystic fibrosis transmembrane …

Cystic fibrosis is caused by dysfunction of the cystic fibrosis transmembrane conductance
regulator (CFTR) protein, leading to altered ion transport, chronic infection, and excessive …

The cystic fibrosis (CF) transmembrane regulator (CFTR) is a cyclic AMP-dependent Cl−
channel that is defective in CF cells. It has been hypothesized that CFTR exhibits an ATP …

Airway epithelia are confronted with distinct signals emanating from the luminal and/or
serosal environments. This study tested whether airway epithelia exhibit polarized …

Two Cl− conductances have been described in the apical membrane of both human and
murine proximal airway epithelia that are thought to play predominant roles in airway …

A key aspect of the lung's innate defense system is the ability of the superficial epithelium to
regulate airway surface liquid (ASL) volume to maintain a 7-μm periciliary liquid layer (PCL) …

The cystic fibrosis transmembrane conductance regulator (CFTR) functions to regulate both
CI− and Na+ conductive pathways; however, the cellular mechanisms whereby CFTR acts …

The cystic fibrosis transmembrane conductance regulator CFTR gene is found on
chromosome 7 [Kerem, B., Rommens, JM, Buchanan, JA, Markiewicz, D., Cox, TK …

The volume and composition of a thin layer of liquid covering the airway surface defend the
lung from inhaled pathogens and debris. Airway epithelia secrete Cl–into the airway surface …

Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) Cl− channel, which mediates transepithelial Cl− transport in a variety of …