In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …

Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …

Current deficiency in our understanding of acute-to-chronic pain transition remains a hurdle
for developing effective treatments against chronic pain. Whereas neurocentric mechanisms …

Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …

Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …

Neuropathic pain presents a huge societal and individual burden. The limited efficacy of
current analgesics, diagnostic markers and clinical trial outcome measures arises from an …

Chronic pain is a common and devastating condition that induces well-characterized
changes in neurons and microglia. One major unanswered question is why these changes …

Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of
temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system …

Microglial cells, the resident immune cells of the spinal cord, become activated in response
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …

Microglia are gatekeepers in the CNS for a wide range of pathological stimuli and they blow
the whistle when things go wrong. Collectively, microglia form a CNS tissue alarm system …