Effects of the Staphylococcus aureus and Staphylococcus epidermidis Secretomes Isolated from the Skin Microbiota of Atopic Children on CD4+ T Cell Activation

E Laborel-Préneron, P Bianchi, F Boralevi, P Lehours… - PLoS …, 2015 - journals.plos.org
Interactions between the immune system and skin bacteria are of major importance in the
pathophysiology of atopic dermatitis (AD), yet our understanding of them is limited. From a …

Microbiome and pediatric atopic dermatitis

CE Powers, DB McShane, PH Gilligan… - The Journal of …, 2015 - Wiley Online Library
Atopic dermatitis is a chronic inflammatory skin condition with drastic impacts on pediatric
health. The pathogenesis of this common disease is not well understood, and the complex …

Nasal and skin microbiomes are associated with disease severity in paediatric atopic dermatitis

JEE Totté, LM Pardo, KB Fieten, MC Vos… - British Journal of …, 2019 - academic.oup.com
Background Alterations of the skin microbiome have been associated with atopic dermatitis
(AD) and its severity. The nasal microbiome in relation to AD severity is less well studied …

Role of the microbiota in skin immunity and atopic dermatitis

Y Yamazaki, Y Nakamura, G Núñez - Allergology International, 2017 - jstage.jst.go.jp
abstract Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects 15e20% of
children and 2e5% of adults in industrialized countries. The pathogen Staphylococcus …

The skin microbiome of patients with atopic dermatitis normalizes gradually during treatment

VD Khadka, FM Key, C Romo-González… - Frontiers in Cellular …, 2021 - frontiersin.org
Background Atopic dermatitis (AD) is characterized by an altered skin microbiome
dominantly colonized by S. aureus. Standard treatment includes emollients, anti …

Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis

AL Byrd, C Deming, SKB Cassidy… - Science translational …, 2017 - science.org
The heterogeneous course, severity, and treatment responses among patients with atopic
dermatitis (AD; eczema) highlight the complexity of this multifactorial disease. Prior studies …

Regulation of T cell immunity in atopic dermatitis by microbes: the yin and yang of cutaneous inflammation

T Biedermann, Y Skabytska, S Kaesler… - Frontiers in …, 2015 - frontiersin.org
Atopic dermatitis (AD) is a chronic inflammatory skin disease predominantly mediated by T
helper cells. While numerous adaptive immune mechanisms in AD pathophysiology have …

Cutaneous dysbiosis may amplify barrier dysfunction in patients with atopic dermatitis

M Hammond, A Gamal, PK Mukherjee… - Frontiers in …, 2022 - frontiersin.org
Atopic dermatitis (AD) is associated with cutaneous dysbiosis, barrier defects, and immune
dysregulation, but the interplay between these factors needs further study. Early-onset …

Skin microbiome dysbiosis and the role of Staphylococcus aureus in atopic dermatitis in adults and children: A narrative review

AL Demessant‐Flavigny, S Connétable… - Journal of the …, 2023 - Wiley Online Library
A dysfunctional epidermal barrier, which may be associated with mutations in the filaggrin
gene in genetically predisposed individuals or harmful effects of environmental agents and …

The role of the skin microbiome in atopic dermatitis

T Nakatsuji, RL Gallo - Annals of Allergy, Asthma & Immunology, 2019 - Elsevier
Atopic dermatitis (AD) is a common inflammatory skin disease associated with significant
medical burden, affecting 15% to 20% of children and 1% to 3% of adults worldwide. 1 The …