Amiodarone is a benzofuran derivative used to treat arrhythmias, but its use is limited by
adverse reactions. There is evidence that some of the severe adverse reactions such as liver …

Amiodarone (AMD), a class III antiarrhythmic drug, causes idiosyncratic hepatotoxicity in
human patients. We demonstrated previously that tumor necrosis factor-alpha (TNF-α) plays …

Amiodarone can cause pulmonary toxicity along with an increase in phospholipid in
macrophages, lymphocytes, and other cell types. Phospholipid accumulates because …

Background: The clinical usefulness of amiodarone for the treatment of cardiac arrhythmias
is limited by multiorgan toxicity, especially pulmonary and hepatic. There are conflicting …

Amiodarone (AM) is an effective antidysrhythmic agent, restricted in use by the development
of adverse effects, including potentially fatal AM‐induced pulmonary toxicity (AIPT). Although …

Amiodarone-induced pulmonary toxicity is a serious side-effect, but the underlying
molecular mechanisms remain unclear. We examined phospholipidosis and apoptosis in rat …

Abstract Amiodarone [2-butyl-3-(3′, 5′-diiodo-4'α-diethylaminoethoxybenzoyl)-
benzofuran](AMD), a class III antiarrhythmic drug, is known to cause idiosyncratic …

Drug‐induced liver injury (DILI) is the most frequent cause of post‐marketing warnings and
withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans …

Amiodarone is a class III antiarrhythmic drug with potentially life-threatening hepatotoxicity.
Recent in vitro investigations suggested that the mono-N-desethyl (MDEA) and di-N …

Amiodarone is one of the most effective anti-arrhythmic drugs available. However, its use is
often limited by potentially life-threatening toxicities, including hepatotoxicity and pulmonary …