The design of an adaptive clinical trial to evaluate the efficacy of platelets stored at low temperature in surgical patients

E Krachey, K Viele, PC Spinella… - Journal of Trauma …, 2018 - journals.lww.com
BACKGROUND Storage of platelets at 4 C compared with 22 C may increase both
hemostatic activity and storage duration; however, the maximum duration of cold storage is …

Design and logistical considerations for the randomized adaptive non-inferiority storage-duration-ranging CHIlled Platelet Study

ND Zantek, ME Steiner, JM VanBuren… - Clinical …, 2023 - journals.sagepub.com
Background: Platelet transfusion is a potentially life-saving therapy for actively bleeding
patients, ranging from those undergoing planned surgical procedures to those suffering …

A Pilot Trial of Platelets Stored Cold versus at Room Temperature for Complex Cardiothoracic Surgery

G Strandenes, J Sivertsen, CK Bjerkvig, TK Fosse… - …, 2020 - pubs.asahq.org
Background This pilot trial focused on feasibility and safety to provide preliminary data to
evaluate the hemostatic potential of cold-stored platelets (2° to 6° C) compared with …

Postoperative Transfusions after Administration of Delayed Cold-stored Platelets versus Room Temperature Platelets in Cardiac Surgery: A Retrospective Cohort …

AM Klompas, S Zec, AC Hanson, T Weister… - …, 2023 - pubs.asahq.org
Background Delayed cold storage of room temperature platelets may extend shelf life from 5
to 14 days. The study hypothesized that the use of delayed cold-stored platelets in cardiac …

A pilot randomized clinical trial of cryopreserved versus liquid‐stored platelet transfusion for bleeding in cardiac surgery: the cryopreserved versus liquid platelet‐New …

S McGuinness, R Charlewood, E Gilder… - Vox …, 2022 - Wiley Online Library
Abstract Background and Objectives Platelets for transfusion have a shelf‐life of 7 days,
limiting availability and leading to wastage. Cryopreservation at− 80° C extends shelf‐life to …

Cold-stored platelets for acute bleeding in cardiac surgical patients: a narrative review

J Lu, K Karkouti, M Peer, M Englesakis… - Canadian Journal of …, 2023 - Springer
Purpose Cold-stored platelets (CSP) are an increasingly active topic of international
research. They are maintained at 1–6° C, in contrast to standard room-temperature platelets …

A randomized, controlled pilot clinical trial of cryopreserved platelets for perioperative surgical bleeding: the CLIP‐I trial (Editorial, p. 2759)

MC Reade, DC Marks, R Bellomo, R Deans… - …, 2019 - Wiley Online Library
BACKGROUND Cryopreservation extends platelet (PLT) shelf life from 5 to 7 days to 2 to 4
years. However, only 73 patients have been transfused cryopreserved PLTs in published …

[HTML][HTML] Design of the randomized controlled trial comparing dimethyl sulfoxide cryopreserved platelets to liquid stored platelets in patients undergoing …

G Whitman, R Kramer, K Tanaka, J Holcomb… - JTCVS open, 2023 - Elsevier
Objective Dimethylsulfoxide-cryopreserved platelets are being evaluated for treatment of
acute hemorrhage in patients with thrombocytopenia or platelet dysfunction when liquid …

A clinical trial of frozen platelets: rationale, protocol and pilot analysis plan

DC Marks, L Johnson, MC Reade - ISBT Science Series, 2018 - Wiley Online Library
Introduction Platelets have a short shelf life and may be discarded due to expiry. Smaller
Australian hospitals often cannot justify keeping platelet units on‐site. Cryopreserved …

Warming up to cold-stored platelets

CS Cohn, BH Shaz - Anesthesiology, 2020 - pubs.asahq.org
Platelets are critical in stopping hemorrhage as they treat the underlying coagulopathy and
improve patient outcomes. However, maintaining an adequate platelet supply is …