J. Neurochem.(2010) 112, 1305–1315. Abstract Frontotemporal dementia with ubiquitin‐
positive inclusions (FTLD‐U) can be caused by mutations in the progranulin gene (GRN) …

Loss of function mutations in progranulin cause tau-negative frontotemporal lobar
degeneration with ubiquitin-positive inclusions. A major protein component of these …

Background Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal
lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed …

Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin
(PGRN), are a major cause of frontotemporal dementia (FTD). GRN-associated FTD is …

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is characterized by
progressive decline in behavior, executive function, and language. Progranulin (GRN) gene …

Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …

Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience
community with recent discoveries of mutations in the gene for PGRN that cause …

Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal
lobar degeneration (FTLD), the second most common cause of early-onset dementia …

Progranulin (GRN) is a secreted growth factor involved in various cellular functions, and loss-
of-function mutations are a major cause of frontotemporal lobar degeneration (FTLD) with …

Frontotemporal lobar degeneration (FTLD) is a pathological process characterized by
severe atrophy in the frontal and temporal lobes of the brain (Mackenzie et al., 2011). There …