Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its
function in the central nervous system is unknown. Roles in development, sexual …

Progranulin (GRN) mutations are associated with different clinical phenotypes, including
Frontotemporal Lobar Degeneration (FTLD), Corticobasal Degeneration and Alzheimer's …

In 2006, mutations in the granulin gene were identified in patients with familial
Frontotemporal Lobar Degeneration. Granulin transcript haploinsufficiency has been …

Abstract Ubiquitin‐positive, tau‐negative, frontotemporal dementia (FTD) is caused by null
mutations in progranulin (PGRN; HUGO gene symbol GRN), suggesting a haploinsufficiency …

Long‐term or severe lack of protective factors is important in the pathogenesis of
neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly …

Granulin (Grn) mutations were identified in familial frontotemporal lobar degeneration
(FTLD) patients with TAR DNA-binding protein of 43 kd (TDP-43) pathology. Grn transcript …

Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disease with
an age at onset generally below 65 years. Mutations in progranulin (GRN) have been …

Mutations in the gene encoding granulin (HUGO gene symbol GRN, also referred to as
progranulin, PGRN), located at chromosome 17q21, were recently linked to tau‐negative …

Frontotemporal dementia (FTD) is a neurodegenerative disease, leading to behavioral
changes and language difficulties. Heterozygous loss-of-function mutations in progranulin …

Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary
frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to …