Purpose The proto-oncogene MYCN is considered a transcription factor involved in the
regulation of neuroblastoma (NB) cell biology. Since minimally invasive-surgery represents …

Introduction CO 2 pneumoperitoneum can influence the biological behavior of
neuroblastoma (NB). Angiogenesis and genetic features are responsible for malignant …

The ablative role of minimally invasive surgery (MIS) in neuroblastoma (NB) is still
controversial due to the possible CO₂ pneumoperitoneum side-effects on tumor …

Purpose: It has been reported that CO 2 gas, used to establish a pneumoperitoneum during
laparoscopy, affects the behavior of tumor cells. The proto-oncogenes c-myc and HMGB-1 …

Purpose We evaluated in vitro the role of CO 2-induced oxidative stress on the expression of
proteins involved in cell-cycle regulation of neuroblastoma cells. Methods SH-SY5Y cells …

Background The response of mesothelial cells to surgical trauma and bacterial
contamination is poorly defined. We have recently shown that CO 2 pneumoperitoneum …

We read with great interest the article by Kılınç et al1 and we congratulate the authors for a
well-designed prospective, observational study. The authors perioperatively monitored the …

Background CO 2 pneumoperitoneum provides a new surgical environment to treat
malignant disease. The purpose of this study was to investigate the influence of CO 2 …

Minimally invasive surgery (MIS) for cancer patients has become widely accepted in general
surgery, however, it has not completely replaced the standard open operative procedures in …

Abstract Background Carbon-dioxide (CO 2)-pneumothorax during minimally invasive
surgery induces well-known metabolic changes. However, little is known about its impact on …