Bitter taste receptors (T2Rs) are GPCRs involved in detection of bitter compounds by type 2
taste cells of the tongue, but are also expressed in other tissues throughout the body …

Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

The human G-protein-coupled bitter taste receptor T2R38 has recently been demonstrated
to be expressed on peripheral blood neutrophils, monocytes and lymphocytes. To further …

Taste buds are the transducing endorgans of gustation. Each taste bud comprises 50–100
elongated cells, which extend from the basal lamina to the surface of the tongue, where their …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

In addition to being responsible for bitter taste, type 2 taste receptors (T2Rs) regulate
endocrine, behavioral, and immunological responses. T2R agonists include indicators of …

G protein-coupled receptors (GPCRs) play a vital role in transmitting an extracellular stimuli
or signal into an intracellular response in various cells. In some scenarios, GPCRs or their …

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including
secreted bacterial products. Here, using human primary sinonasal air-liquid interface …

Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …

Background Bitter taste receptors (T2R) have recently been demonstrated to contribute to
sinonasal innate immunity. One T2R, T2R38, regulates mucosal defense against gram …