Frontotemporal lobar degeneration

M Grossman, WW Seeley, AL Boxer, AE Hillis… - Nature Reviews …, 2023 - nature.com
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

Frontotemporal lobar degeneration: epidemiology, pathology, diagnosis and management

RE Seltman, BR Matthews - CNS drugs, 2012 - Springer
Frontotemporal lobar degeneration (FTLD) describes a spectrum of clinically, pathologically
and genetically heterogeneous neurodegenerative disorders of unknown aetiology. FTLD …

FUS pathology defines the majority of tau-and TDP-43-negative frontotemporal lobar degeneration

H Urwin, KA Josephs, JD Rohrer, IR Mackenzie… - Acta …, 2010 - Springer
Through an international consortium, we have collected 37 tau-and TAR DNA-binding
protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, and present …

Development of disease-modifying drugs for frontotemporal dementia spectrum disorders

F Panza, M Lozupone, D Seripa, A Daniele… - Nature Reviews …, 2020 - nature.com
Frontotemporal dementia (FTD) encompasses a spectrum of clinical syndromes
characterized by progressive executive, behavioural and language dysfunction. The various …

neuropathology of non‐tau frontotemporal lobar degeneration

M Neumann, IRA Mackenzie - Neuropathology and applied …, 2019 - Wiley Online Library
Frontotemporal dementia (FTD) is a heterogeneous clinical syndrome associated with
frontotemporal lobar degeneration (FTLD) as a relatively consistent neuropathological …

Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

DJ Irwin, NJ Cairns, M Grossman, CT McMillan… - Acta …, 2015 - Springer
Frontotemporal lobar degeneration (FTLD) comprises two main classes of
neurodegenerative diseases characterized by neuronal/glial proteinaceous inclusions (ie …

New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures

AL Boxer, M Gold, H Feldman, BF Boeve… - Alzheimer's & …, 2019 - Elsevier
Introduction Frontotemporal lobar degeneration (FTLD) is the most common form of
dementia for those under 60 years of age. Increasing numbers of therapeutics targeting …

Frontotemporal lobar degeneration: epidemiology, pathophysiology, diagnosis and management

GD Rabinovici, BL Miller - CNS drugs, 2010 - Springer
Frontotemporal lobar degeneration (FTLD) is a clinically and pathologically heterogeneous
syndrome, characterized by progressive decline in behaviour or language associated with …

A new subtype of frontotemporal lobar degeneration with FUS pathology

M Neumann, R Rademakers, S Roeber, M Baker… - Brain, 2009 - academic.oup.com
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular
basis. The neuropathology associated with most FTD is characterized by abnormal cellular …

Frontotemporal dementia: correlations between psychiatric symptoms and pathology

M Scarioni, P Gami‐Patel, Y Timar… - Annals of …, 2020 - Wiley Online Library
Objective The pathology of frontotemporal dementia, termed frontotemporal lobar
degeneration (FTLD), is characterized by distinct molecular classes of aggregated proteins …