Sialylation is a dynamically regulated modification, which commonly occurs at the terminal of
glycan chains in glycoproteins and glycolipids in eukaryotic cells. Sialylation plays a key role …

Sialic acid (Sia), the acylated derivative of the nine-carbon sugar neuraminic acid, is a
terminal component of the oligosaccharide chains of many glycoproteins and glycolipids. In …

In the modern world, cardiovascular diseases have a special place among the most
common causes of death. Naturally, this widespread problem cannot escape the attention of …

Background Chronic vascular disease atherosclerosis starts with an uptake of atherogenic
modified low‐density lipoproteins (LDLs) by resident macrophages, resulting in formation of …

Deficit sialylation of vascular endothelium, circulating cells and macromolecules has been
associated with the development of atherosclerosis. On the other hand, an elevated serum …

Plasma levels of non–high-density (non-HDL) cholesterol are causally linked to the risk of
coronary artery disease. Non-HDL cholesterol levels are a better predictor of cardiovascular …

Vascular endothelia are covered with a dense glycocalix that is heavily sialylated.
Sialylation of vascular glycoconjugates is involved in the regulation of cell–cell interactions …

Atherosclerosis is a complex disease that involves alterations in lipoprotein metabolism and
inflammation. Protein and lipid glycosylation events, such as sialylation, contribute to the …

Lipoprotein metabolism is an important contributing factor in the development and
progression of atherosclerosis. Plasma lipoproteins and their receptors are heavily …

Low density lipoprotein (LDL) with low sialic acid content has been reported to cause
intracellular cholesterol accumulation, and therefore desialylation has been proposed to be …