Phase 2a, open-label, dose-escalating, multi-center pharmacokinetic study of favipiravir (T-705) in combination with oseltamivir in patients with severe influenza
Background The pharmacokinetics and appropriate dose regimens of favipiravir are
unknown in hospitalized influenza patients; such data are also needed to determine dosage …
unknown in hospitalized influenza patients; such data are also needed to determine dosage …
Understanding the pharmacokinetics of Favipiravir: Implications for treatment of influenza and COVID-19
MG Ison, MH Scheetz - EBioMedicine, 2021 - thelancet.com
Favipiravir (T-705; 6-fluoro-3‑hydroxy-2-pyrazinecarboxamide) is an orally bioavailable
nucleoside analog that selectively inhibits the PB1 subunit of the RNA-dependent RNA …
nucleoside analog that selectively inhibits the PB1 subunit of the RNA-dependent RNA …
Oral favipiravir exposure and pharmacodynamic effects in adult outpatients with acute influenza
FG Hayden, RP Lenk, C Epstein… - The Journal of Infectious …, 2024 - academic.oup.com
Background The pharmacokinetics of oral favipiravir and the relationships of plasma
concentrations to antiviral effects are incompletely studied in influenza. Methods Serial …
concentrations to antiviral effects are incompletely studied in influenza. Methods Serial …
Favipiravir treatment of uncomplicated influenza in adults: results of two phase 3, randomized, double-blind, placebo-controlled trials
FG Hayden, RP Lenk, L Stonis… - The Journal of …, 2022 - academic.oup.com
Background We conducted double-blind, placebo-controlled trials assessing the efficacy
and tolerability of favipiravir in acute influenza. Methods Otherwise healthy adults with …
and tolerability of favipiravir in acute influenza. Methods Otherwise healthy adults with …
Comparative effectiveness of combined favipiravir and oseltamivir therapy versus oseltamivir monotherapy in critically ill patients with influenza virus infection
Background A synergistic effect of combination therapy with favipiravir and oseltamivir has
been reported in preclinical models of influenza. However, no data are available on the …
been reported in preclinical models of influenza. However, no data are available on the …
Potential repurposing of Favipiravir in COVID-19 outbreak based on current evidence
K Khambholja, D Asudani - Travel medicine and infectious disease, 2020 - ncbi.nlm.nih.gov
As reviewed by Cao et al., the availability of results of previous research studies helped in
prioritizing clinical trials for Remdesivir [1]. The molecule was covered in WHO's Director …
prioritizing clinical trials for Remdesivir [1]. The molecule was covered in WHO's Director …
US201 study: a phase 2, randomized proof-of-concept trial of favipiravir for the treatment of COVID-19
RW Finberg, M Ashraf, B Julg, F Ayoade… - Open forum …, 2021 - academic.oup.com
Background Favipiravir is used to treat influenza, and studies demonstrate that it has
antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
A prospective, randomized, open-label trial of early versus late favipiravir therapy in hospitalized patients with COVID-19
Y Doi, M Hibino, R Hase, M Yamamoto… - Antimicrobial agents …, 2020 - Am Soc Microbiol
Favipiravir is an oral broad-spectrum inhibitor of viral RNA-dependent RNA polymerase that
is approved for treatment of influenza in Japan. We conducted a prospective, randomized …
is approved for treatment of influenza in Japan. We conducted a prospective, randomized …
Favipiravir: pharmacokinetics and concerns about clinical trials for 2019‐nCoV infection
YX Du, XP Chen - Clinical Pharmacology & Therapeutics, 2020 - Wiley Online Library
An outbreak of 2019‐nCoV infection has spread across the world. No specific antiviral drugs
have been approved for the treatment of COVID‐2019. In addition to the recommended …
have been approved for the treatment of COVID‐2019. In addition to the recommended …
Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial
V Luvira, WHK Schilling, P Jittamala, JA Watson… - BMC Infectious …, 2024 - Springer
Brief summary In early symptomatic COVID-19 treatment, high dose oral favipiravir did not
accelerate viral clearance. Background Favipiravir, an anti-influenza drug, has in vitro …
accelerate viral clearance. Background Favipiravir, an anti-influenza drug, has in vitro …