The receptor binding and proteolysis of Spike of SARS-CoV-2 release its S2 subunit to
rearrange and catalyze viral-cell fusion. This deploys the fusion peptide for insertion into the …

Coronavirus disease-2019 (COVID-19), a potentially lethal respiratory illness caused by the
coronavirus SARS-CoV-2, emerged in the end of 2019 and has since spread aggressively …

The entry of SARS-CoV-2 into host cells depends on the refolding of the virus-encoded
spike protein from a prefusion conformation, which is metastable after cleavage, to a lower …

During infection the SARS-CoV-2 virus fuses its viral envelope with cellular membranes of
its human host. The viral spike (S) protein mediates both the initial contact with the host cell …

Intervention strategies are urgently needed to control the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pandemic. The trimeric viral spike (S) protein catalyzes fusion …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly contagious, and
transmission involves a series of processes that may be targeted by vaccines and …

SARS-CoV-2 cell entry is completed after viral spike (S) protein–mediated membrane fusion
between viral and host cell membranes. Stable prefusion and postfusion S structures have …

Infection of human cells by the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV2) relies on its binding to a specific receptor and subsequent fusion of the viral and host …

The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the
dominant target of the immune system. It exhibits substantial conformational flexibility. It …

Viral membrane fusion is an orchestrated process triggered by membrane-anchored viral
fusion glycoproteins. The S2 subunit of the spike glycoprotein from severe acute respiratory …