RNA-based nanostructures and molecular devices have become popular for developing
biosensors and genetic regulators. These programmable RNA nanodevices can be …

Highlights•Palette of fluorogenic RNA-dye pairs now are available for biosensor
engineering.•RNA-based fluorescent biosensors developed for molecular imaging …

Light-up RNA aptamers are valuable tools for fluorescence imaging of RNA in living cells
and thus for elucidating RNA functions and dynamics. However, no light-up RNA sensor has …

Herein, a time-resolved luminescence resonance energy transfer (TR-LRET) molecular
beacon (MB) probe employing persistent luminescence nanoparticles (PLNPs) as the …

Here we report the design of a bioluminescence resonance energy transfer (BRET)-based
sensing system that could detect nucleic acid target in 5min with high sensitivity and …

Fluorescent RNA (FR)-based genetically encoded sensors have been engineered to detect
various essential metabolites in living systems. However, the unfavorable characteristics of …

RNAs directly regulate a vast array of cellular processes, emphasizing the need for robust
approaches to fluorescently label and track RNAs in living cells. Here, we develop an RNA …

Live cell imaging of RNAs is crucial to interrogate their fundamental roles in various
biological processes. The highly spatiotemporal dynamic nature of RNA abundance and …

Benefiting from superior programmable performance and flexible design of DNA
technologies, a variety of single-molecule RNA fluorescence imaging methodologies have …

Imaging the cellular dynamics of metabolites and signaling molecules is critical for
understanding various metabolism and signal transduction pathways. Genetically encoded …