Early life adversity can have a significant long-term impact with implications for the
emergence of psychopathology. Disruption to mother-infant interactions is a form of early life …

Background Childhood adversity is associated with increased risk for mood, anxiety,
impulse control, and substance disorders. Although genetic and environmental factors …

During postnatal development, adverse early life experiences affect the formation of
neuronal networks and exert long-lasting effects on neural function. Many studies have …

Early life adversities together with genetic predispositions have been associated with
elevated risks of neuropsychiatric disorders during later life. In order to investigate the …

The developing brains of young children are highly sensitive to input from their social
environment. Nurturing social experience during this time promotes the acquisition of social …

The long-term impact of early stress on behavior and emotions is well documented in
humans, and can be modeled in experimental animals. In mice, maternal separation during …

Early life stress (ELS) is a potent developmental disruptor and increases the risk for
psychopathology. Various forms of ELS have been studied in both humans and rodents, and …

Abstract Development is a dynamic process that involves interplay between genes and the
environment. In mammals, the quality of the postnatal environment is shaped by parent …

Adverse early life experience, such as childhood abuse, neglect, and trauma, increases
lifetime risk for mental illness. To investigate underlying mechanisms, the maternal …

Accumulating evidence suggests that adversities at critical periods in early life, both pre-and
postnatal, can lead to neuroendocrine perturbations, including hypothalamic-pituitary …