Hypoxic signaling is involved in homeostatic and developmental angiogenic and
neurogenic proliferation and differentiation as well as modulating many disease processes …

The cardiovascular system (CVS) consists of heart and blood vessels, forming a close
circulatory loop. All tissues depend on the nutrients and molecular oxygen (O2) delivered by …

Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in
vertebrates they are known to participate in several developmental processes, including …

The availability of new tools to study the activation of specific cells signaling regulating cell
survival and death, proliferation and differentiation are the new frontiers for understanding in …

Introduction: Hypoxia drives pathological angiogenesis but the contribution of hemodynamic
force in these processes is unknown. Mutations in von hippel lindau protein (vhl) upregulate …

The availability of new tools to study the activation of specific cells signaling regulating cell
survival and death, proliferation and differentiation are the new frontiers for understanding in …

Abstract Background Hypoxia Inducible Factor (HIF) regulates a cascade of transcriptional
events in response to decreased oxygenation, acting from the cellular to the physiological …

The hypoxia inducible transcription factor (HIF) has been shown to coordinate the hypoxic
response of vertebrates and is expressed in three different isoforms, HIF-1α, HIF-2α and HIF …

Oxygen is a central molecule in the development of multicellular life, allowing efficient
energy generation. Inadequate oxygen supply requires rapid adaptations to prevent cellular …

Hypoxia-inducible factors (HIFs) regulate gene expression in response to hypoxia and in
vertebrates they are known to participate in several developmental processes, including …