The development of metastasis severely reduces the life expectancy of patients with
colorectal cancer (CRC). Although loss of SMAD4 is a key event in CRC progression, the …

Smad4 is a tumor suppressor gene primarily involved in carcinogenesis of the pancreas and
colon. The functional inactivation of Smad4 is a late step genetically. In pancreatic …

Growth and metastasis of colorectal cancer is closely connected to the biosynthetic capacity
of tumor cells, and colorectal cancer stem cells that reside at the top of the intratumoral …

Background Colorectal cancer is the second‐leading cause of cancer‐related mortality in
the United States and a leading cause of cancer‐related mortality worldwide. Loss of …

Background SMAD family member 4 (SMAD4) has gained attention as a promising
prognostic factor of colorectal cancer (CRC) as well as a key molecule to understand the …

The cell of origin of colon cancer is typically thought to be the resident somatic stem cells,
which are immortal and escape the continual cellular turnover characteristic of the intestinal …

Purpose: We previously reported that loss of SMAD4 promotes chemokine CCL15
expression to recruit CCR1+ myeloid cells via the CCL15–CCR1 axis, which facilitates …

Background & Aims SMAD4 frequently is lost from colorectal cancers (CRCs), which is
associated with the development of metastases and a poor prognosis. SMAD4 loss is …

Colorectal cancer progression is intrinsically linked to stepwise deregulation of the intestinal
differentiation trajectory. In this process, sequential mutations of APC, KRAS, TP53, and …

Background & Aims Chronic inflammation is a predisposing condition for colorectal cancer.
Many studies to date have focused on proinflammatory signaling pathways in the colon …