Granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) activation with ligand
binding induces myeloid cell proliferation, survival, and differentiation. 1 Acquired somatic …

Abstract The Severe Chronic Neutropenia International Registry (SCNIR) in cooperation
with Washington University has developed a next-generation sequencing assay for the …

Neutropenia is condition characterized by low number of neutrophils in circulation. This
leads to an increased risk of infections and is often diagnosed early in life. Extreme cases …

Severe congenital neutropenia (SCN) is a collection of diverse disorders characterized by
chronically low absolute neutrophil count in the peripheral blood, increased susceptibility to …

Congenital neutropenia (CN) is a rare disorder, and the most common gene responsible for
CN is ELANE. Furthermore, the mutations of HAX1, G6PC3, and JAGN1 genes may cause …

Several mechanisms have been proposed to explain the pathogenesis of severe congenital
neutropenia (SCN); however, the mechanism (s) still remains unknown. In particular, clinical …

The term congenital neutropenia (CN) has been used for a group of hematologic disorders
characterized by severe neutropenia with absolute neutrophil counts (ANC) below 0.5 x 10 …

Although several mechanisms have been proposed to explain the pathophysiology of
severe congenital neutropenia (SCN), the precise defect responsible for SCN remains …

Hematol Oncol Clin N Am 27 (2013) 61–73 http://dx. doi. org/10.1016/j. hoc. 2012.10. 002
hemonc. theclinics. com 0889-8588/13/$–see front matter© 2013 Elsevier Inc. All rights …

Severe congenital neutropenia (SCN) is caused by germline mutations, most commonly in
ELANE, impacting neutrophil maturation and leading to high risk of life-threatening …