25 Background: Over the last decade recombinant human granulocyte-colony stimulating
factor (G-CSF) has had a major impact on management of" severe chronic neutropenia", a …

Abstract Severe Congenital Neutropenia (SCN) is a rare inherited disease characterized by
an absolute neutrophil count (ANC) lower than 500/μL. Genetic heterogeneity and biallelic …

Severe congenital neutropenia (SCN) is a rare primary immunodeficiency disease. Different
genes are found to be associated with SCN, including ELA2, HAX1, WAS, GFI1, G-CSFR …

Congenital neutropenia: disease models guiding new treatment... : Current Opinion in
Hematology Congenital neutropenia: disease models guiding new treatment strategies : Current …

Severe congenital neutropenia is a group of rare diseases, characterized by a severe
depletion of absolute neutrophil count which can be isolated or associated to …

Severe congenital neutropenia (SCN) is an inborn disorder of granulopoiesis characterized
by severe chronic neutropenia from birth, premature death secondary to infectious …

Severe congenital neutropenia (SCN) is characterized by low numbers of peripheral
neutrophil granulocytes and a predisposition to life-threatening bacterial infections. We …

The treatment of children affected by severe congenital neutropenia (SCN) with G-CSF
strongly reduces the risk of sepsis by reversing neutropenia. However, SCN patients who …

Neutrophils (and monocytes) from 5 patients suffering from severe congenital neutropenia
(SCN) were investigated in vitro after induction of this cell type by treatment with …

Severe congenital neutropenia (CN; Kostmann syndrome) is a hematologic disorder
characterized by a maturation arrest of myelopoiesis at the promyelocyte/myelocyte stage of …