Primordial germ cells (PGCs), the precursors of sperm and eggs, are the route to totipotency
and require establishment of a unique epigenome in this lineage. The genetic program for …

Genome-wide active DNA demethylation in primordial germ cells (PGCs), which reprograms
the epigenome for totipotency, is linked to changes in nuclear architecture, loss of histone …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

Germline cells reprogramme extensive epigenetic modifications to ensure the cellular
totipotency of subsequent generations and to prevent the accumulation of epimutations …

Epigenetic reprogramming is a central process during mammalian germline development.
Genome-wide DNA demethylation in primordial germ cells (PGCs) is a prerequisite for the …

Primordial germ cells (PGCs) are undifferentiated germ line cells in embryos that emerge at
early stages of embryonic development, and then differentiate into eggs or sperm in gonads …

Epigenetic reprogramming, characterized by loss of cytosine methylation and histone
modifications, occurs during mammalian development in primordial germ cells (PGCs), yet …

Primordial germ cell (PGC) development is characterized by global epigenetic remodeling,
which resets genomic potential and establishes an epigenetic ground state. Here we …

In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

DNA methylation is a carrier of important regulatory information that undergoes global
reprogramming in the mammalian germ line, including pre-implantation embryos and …