Osteogenesis imperfecta (OI) is a disease encompassing a group of disorders mainly
characterized by bone fragility and is the most common form of heritable bone fragility. There …

Osteogenesis imperfecta (OI) is a heritable disease of bone with low bone mass and bone
fragility. The disease is generally classified into four types based on clinical features and …

Osteogenesis imperfecta (OI), or brittle bone disease, a rare heritable connective tissue
disorder, was described more than a century ago.(1) Its hallmark, bone fragility, may cause …

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Osteogenesis imperfecta (OI), also known as brittle bone disease, is a set of genetically and
clinically heterogeneous conditions characterized by bone fragility, susceptibility to fractures …

Osteogenesis imperfecta (OI) is a group of rare, inherited disorders with genetic and clinical
diversities. With a prevalence of 1: 10,000–1: 20,000, OI is considered as an “orphan …

Osteogenesis imperfecta (OI) is a group of rare heritable disorders characterized by varying
degrees of low bone mass and bone fragility. Overall, OI has an estimated prevalence of …

Osteogenesis imperfecta (OI) is a relatively common genetic skeletal disorder with an
estimated frequency of 1 in 20 000 worldwide. The manifestations are diverse and although …

Recently, the genetic heterogeneity in osteogenesis imperfecta (OI), proposed in 1979 by
Sillence et al., has been confirmed with molecular genetic studies. At present, 17 genetic …

Osteogenesis imperfecta (OI) is a rare genetic disease. Today we are able to propose an
adapted and efficient management to the patients with this rare disorder (and their families) …