Although the pathogenesis of Alzheimer's disease (AD) remains unclear, some molecular
aspects that precede or accompany the deposit of β-amyloid in senile plaques attract …

Recent reports demonstrate that the activation and interaction of the protease calpain (CP)
and the protein phosphatase calcineurin (CN) are elevated in the late stages of Alzheimer's …

Interleukin-1β (IL-1β) and the Ca 2+/calmodulin-dependent protein phosphatase,
calcineurin, have each been shown to play an important role in neuroinflammation …

Calcineurin is an abundant cytosolic protein that is implicated in the modulation of glutamate
release. Here we show that the expression level of this enzyme is reduced in primary …

Alzheimer's disease (AD) is a progressive, age-related neurodegenerative disorder which
first manifests as profound memory dysfunction. The majority of cases are idiopathic …

Amyloid β (Aβ) peptides, the main pathological species associated with Alzheimer's disease
(AD), disturb intracellular calcium homeostasis, which in turn activates the calcium …

A disturbance of calcium homeostasis is believed to play an important role in the
neurodegeneration of the brains of Alzheimer disease (AD) patients, but the molecular …

Amyloid-beta protein (Aβ) and the scrapie isoform of prion protein (PrPSs) have a central
role in the pathogenesis of Alzheimer's disease (AD) and prion-related encephalopathies …

Calcineurin is a Ca2+/calmodulin-dependent phosphatase that dephosphorylates numerous
substrates in different neuronal compartments. Genetic and pharmacological studies have …

Astrocyte reactivity (ie, activation) and associated neuroinflammation are increasingly
thought to contribute to neurodegenerative disease. However, the mechanisms that trigger …