Prolonged controlled oxygenated rewarming improves immediate tubular function and energetic recovery of porcine kidneys during normothermic machine perfusion

B Ogurlu, CC Pamplona, IM Van Tricht… - …, 2023 - journals.lww.com
Background. Normothermic machine perfusion (NMP) is typically performed after a period of
hypothermic preservation, which exposes the kidney to an abrupt increase in temperature …

Role of erythrocytes in short‐term rewarming kidney perfusion after cold storage

T Minor, C von Horn, A Paul - Artificial Organs, 2019 - Wiley Online Library
Short term normothermic reconditioning by machine perfusion after cold storage has shown
beneficial effects in renal transplantation models. Systematic investigations concerning the …

Advances in kidney preservation techniques and their application in clinical practice

SA Hosgood, RJ Brown, ML Nicholson - Transplantation, 2021 - journals.lww.com
The use of cold preservation solutions to rapidly flush and cool the kidney followed by static
cold storage in ice has been the standard kidney preservation technique for the last 50 y …

Short, cool, and well oxygenated–HOPE for kidney transplantation in a rodent model

P Kron, A Schlegel, O de Rougemont… - Annals of …, 2016 - journals.lww.com
Objectives: The aim of this study was to investigate novel and easily applicable preservation
perfusion techniques in kidney grafts obtained from donors after circulatory death (DCD) …

Significant dysfunction of kidney grafts exposed to prolonged warm ischemia is minimized through normothermic ex vivo kidney perfusion

P Urbanellis, D Kollmann, I Linares… - Transplantation …, 2020 - journals.lww.com
Background. Normothermic ex vivo kidney perfusion (NEVKP) is an emerging technique for
renal graft preservation. We investigated whether NEVKP could improve early function of …

Prediction of renal function upon reperfusion by ex situ controlled oxygenated rewarming

T Minor, K Sutschet, O Witzke, A Paul… - European Journal of …, 2016 - Wiley Online Library
Background Post‐transplant function of suboptimal kidney grafts can be improved but not
accurately predicted by hypothermic machine perfusion. Therefore, a new concept of ex situ …

Influence of oxygen concentration during hypothermic machine perfusion on porcine kidneys from donation after circulatory death

DP Hoyer, A Gallinat, S Swoboda… - …, 2014 - journals.lww.com
Background Hypothermic machine perfusion (HMP) for preservation led to compelling
success for outcomes of renal transplantation. Application of different concentrations of …

Gradual rewarming with gradual increase in pressure during machine perfusion after cold static preservation reduces kidney ischemia reperfusion injury

P Mahboub, P Ottens, M Seelen, N t Hart, H Van Goor… - PloS one, 2015 - journals.plos.org
In this study we evaluated whether gradual rewarming after the period of cold ischemia
would improve organ quality in an Isolated Perfused Kidney Model. Left rat kidneys were …

Developing an Injury-Free 15 Hour Preservation Protocol of Donor Porcine Kidneys Using Normothermic Machine Perfusion

JP Stone, WR Cowey, CJT Bowers, AF Stewart… - ASAIO …, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) offers a superior alternative to hypothermic
preservation but is currently time limited. Extending this time could electivise transplantation …

Transplantation of cold stored porcine kidneys after controlled oxygenated rewarming

A Gallinat, J Lu, C von Horn, M Kaths… - Artificial …, 2018 - Wiley Online Library
The concept of “controlled oxygenated rewarming”(COR) using ex vivo machine perfusion
after cold storage was evaluated as tool to improve renal graft function after transplantation …