Background Normothermic machine perfusion (NMP) is an alternative strategy for
preserving kidneys donated after cardiac death (DCD). The relative efficacy of prolonged …

Kidney transplantation is limited by hypothermic preservation techniques. Prolonged periods
of cold ischaemia increase the risk of early graft dysfunction and reduce long‐term survival …

Background Hypothermic machine perfusion (HMP) appears to exert a reconditioning effect
on the ischemic damage of kidney grafts. However, some concerns still remain about its real …

Background: Warm reperfusion after previous cold storage has been shown to have a
negative impact on mitochondrial function of organ grafts. Here, we wanted to investigate …

Background Donation after circulatory death (DCD) kidney transplants inevitably sustain a
degree of warm ischaemic injury, which is manifested clinically as delayed graft function …

Purpose The main objective of static cold storage is to reduce cellular metabolic demands to
extend the period of ischaemia prior to transplantation. Hypothermia does not halt …

In deceased donor kidney transplantation (KT), a prolonged cold ischemia time (CIT) is a
negative prognostic factor for KT outcome, and the efficacy of hypothermic machine …

Aim: The scarcity of kidneys for transplantation impels an expansion of the donor source to
include the use of organs from Maastricht II and Maastricht I non heart-beating donors. The …

Organ preservation has historically relied on the concept that by reducing the temperature to
4 C, cellular metabolism is reduced to approximately 10% of normal. 1 Therefore, it is …

Future approaches to expand the organ donor pool with marginal and nonheartbeating
donors, will be dependent upon prospective organ evaluation. Restoration of metabolism by …