Cold preservation sensitizes organ grafts to exacerbation of tissue injury upon reperfusion.
This reperfusion injury is not fully explained by the mere re-introduction of oxygen but rather …

Background. Normothermic machine perfusion (NMP) may allow resuscitation and improved
assessment of kidneys before transplantation. Using discarded human kidneys, we …

The possible reno‐protective effect of a controlled brief heat‐shock treatment during isolated
ex vivo machine perfusion of donor grafts prior to reperfusion should be investigated in a …

Background Cold storage using histidine–tryptophan–ketoglutarate (HTK) solution is used
widely in clinical practice for the preservation of warm ischaemia-damaged kidney grafts …

Gradual rewarming from hypothermic to normothermic is a novel perfusion modality with
superior outcome to sudden rewarming to normothermic. However, the identification of an …

Background. The optimal perfusate partial pressure of oxygen (P o 2) during hypothermic
machine perfusion (HMP) is unknown. The aims of the study were to determine the …

Importance Continuous hypothermic machine perfusion during organ preservation has a
beneficial effect on graft function and survival in kidney transplant when compared with static …

Hemodynamic disorders in brain dead organ donors induce hypoxia, warm ischemia and
finally tissue damage. A cold preservation period also induces tissue and cellular lesions …

With oxygenation proposed as a resuscitative measure during hypothermic models of
preservation, the aim of this study was to evaluate the optimal start time of oxygenation …

Background. Clinical trial data suggest that continuous hypothermic machine perfusion
(HMP) during the entire preservation period reduces the incidence of delayed graft function …