Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson's disease

S Ben Youssef, G Brisson… - Nutritional …, 2021 - Taylor & Francis
Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss
of midbrain dopaminergic (mDA) neurons in the substantia nigra pars compacta, and it …

[HTML][HTML] Plant-derived neuroprotective agents in Parkinson's disease

W Fu, W Zhuang, S Zhou, X Wang - American journal of …, 2015 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is one of the most common degenerative disorders of the central
nervous system among the elderly. The disease is caused by the slow deterioration of the …

[HTML][HTML] A flavonoid-rich extract of mandarin juice counteracts 6-OHDA-induced oxidative stress in SH-SY5Y cells and modulates Parkinson-related genes

S Cirmi, A Maugeri, GE Lombardo, C Russo… - Antioxidants, 2021 - mdpi.com
Parkinson's disease (PD) is a degenerative disorder of the nervous system due to unceasing
impairment of dopaminergic neurons situated in the substantia nigra. At present, anti-PD …

Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease

V Zbarsky, KP Datla, S Parkar, DK Rai… - Free radical …, 2005 - Taylor & Francis
Although the cause of dopaminergic cell death in Parkinson's disease (PD) remains
unknown, oxidative stress has been strongly implicated. Because of their ability to combat …

A Preclinical Systematic Review of Ginsenoside‐Rg1 in Experimental Parkinson's Disease

L Song, MB Xu, XL Zhou, D Zhang… - Oxidative Medicine …, 2017 - Wiley Online Library
To date, no drug has been proven to be neuroprotective or disease‐modifying for
Parkinson's disease (PD) in clinical trials. Here, we aimed to assess preclinical evidence of …

Gastrodin protects apoptotic dopaminergic neurons in a toxin‐induced Parkinson's disease model

H Kumar, IS Kim, SV More, BW Kim… - Evidence‐Based …, 2013 - Wiley Online Library
Gastrodia elata (GE) Blume is one of the most important traditional plants in Oriental
countries and has been used for centuries to improve various conditions. The phenolic …

Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson's disease: motor and non‐motor outcomes

M Bigham, A Mohammadipour, M Hosseini… - Metabolic Brain …, 2021 - Springer
Parkinson's disease (PD) is a common and severe neurodegenerative disorder associated
with a selective loss of dopaminergic neurons in substantia nigra pars compacta. The crucial …

Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease

V Tapias, JR Cannon, JT Greenamyre - Neurobiology of aging, 2014 - Elsevier
Numerous factors contribute to the death of substantia nigra (SN) dopamine (DA) neurons in
Parkinson's disease (PD). Compelling evidence implicates mitochondrial deficiency …

[HTML][HTML] Phenolic characterization and neuroprotective properties of grape pomace extracts

A Chiavaroli, M Balaha, A Acquaviva, C Ferrante… - Molecules, 2021 - mdpi.com
Vitis vinifera (grape) contains various compounds with acknowledged phytochemical and
pharmacological properties. Among the different parts of the plant, pomace is of particular …

[HTML][HTML] GST-4-dependent suppression of neurodegeneration in C. elegans models of Parkinson's and Machado-Joseph disease by rapeseed pomace extract …

F Pohl, A Teixeira-Castro, MD Costa… - Frontiers in …, 2019 - frontiersin.org
Genetic mutations and aging-associated oxidative damage underlie the onset and
progression of neurodegenerative diseases, like Parkinson's disease (PD) and Machado …