Zinc is an essential cofactor required for life and, as such, mechanisms exist for its
homeostatic maintenance in biological systems. Despite the evolutionary distance between …

Among the biologically required first row, late d-block metals from Mn II to Zn II, the catalytic
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …

Zinc is one of the most important metal nutrients for species from all kingdoms, being a key
structural or catalytic component of hundreds of enzymes, crucial for the survival of both …

Due to its favorable chemical properties, zinc is used as a structural or catalytic cofactor in a
very large number of proteins. Despite the apparent abundance of this metal in all cell types …

The innate immune system employs various defense mechanisms to combat invading
microbes. From a pathogen perspective, access to adequate nutrition is one of the …

Innate immune cells such as macrophages and neutrophils initiate protective inflammatory
responses and engage antimicrobial responses to provide frontline defence against …

Zinc is an essential nutrient for all living organisms. However, firm regulation must be
maintained since micronutrients also can be toxic in high concentrations. This notion is …

Zinc is an essential micronutrient known to play a vital role in host defense against
pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery …

The mammalian immune system has evolved sophisticated mechanisms to withhold
essential micronutrients from invading pathogens. These processes, collectively known as …

Zinc is a redox-inert trace element that is second only to iron in abundance in biological
systems. In cells, zinc is typically buffered and bound to metalloproteins, but it may also exist …