Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an
essential micronutrient that is involved in the regulation of the innate and adaptive immune …

Metal ions fulfil a plethora of essential roles within bacterial pathogens. In addition to acting
as necessary cofactors for cellular proteins, making them indispensable for both protein …

Recent studies on pathogenic streptococci have revealed that zinc is a pivotal metal ion in
their interaction with the host. In these streptococci, systems exist that ensure optimal use of …

Iron, zinc and copper, among others, are transition metals with multiple biological roles that
make them essential elements for life. Beyond the strict requirement of transition metals by …

Streptococcus pneumoniae requires manganese for colonization of the human host, but the
underlying molecular basis for this requirement has not been elucidated. Recently, it was …

Transition metals such as iron, zinc, copper, and manganese are essential for the growth
and development of organisms ranging from bacteria to mammals. Numerous studies have …

Zinc is an essential cofactor for bacterial metabolism, and many Enterobacteriaceae express
the zinc transporters ZnuABC and ZupT to acquire this metal in the host. However, the …

Zinc is a ubiquitous metal in all life forms, as it is a structural component of the almost 10% of
eukaryotic proteins, which are called zinc-binding proteins. In zinc-limiting conditions such …

Zinc is necessary for the normal functioning of all living systems. In microbes and mammals
vital biological roles of zinc include the presence of this metal in metalloenzymes and …

All organisms must regulate the cellular uptake, efflux, and intracellular trafficking of
essential elements, including d-block metal ions. In bacteria, such regulation is achieved by …