People with Alzheimer's disease (AD) have significantly higher rates of subclinical and overt
epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

Neuronal activity directly promotes the production and secretion of amyloid β (Aβ).
Interestingly, neuronal hyperactivity can be observed in presymptomatic stages of both …

Human Alzheimer's disease (AD) brains and transgenic AD mouse models manifest
hyperexcitability. This aberrant electrical activity is caused by synaptic dysfunction that …

Cortical and hippocampal network hyperexcitability appears to be an early event in
Alzheimer's disease (AD) pathogenesis, and may contribute to memory impairment. It …

Traditionally, the impairment of cognitive functions in Alzheimeŕs disease (AD) is thought to
result from a reduction in neuronal and synaptic activities, and ultimately cell death. Here …

Network hyperexcitability (NH) has recently been suggested as a potential
neurophysiological indicator of Alzheimer's disease (AD), as new, more accurate biomarkers …

Sporadic late-onset Alzheimer's disease (LOAD), the most common form of dementia in the
elderly, causes progressive and severe loss of cognitive abilities. With greater numbers of …

Soluble amyloid-beta oligomers (Aβo) start to accumulate in the human brain one to two
decades before any clinical symptoms of Alzheimer's disease (AD) and are implicated in …

Early-onset Alzheimer's disease (AD) is associated with variants in amyloid precursor
protein (APP) and presenilin (PSEN) 1 and 2. It is increasingly recognized that patients with …