Ertapenem provides broad-spectrum activity against many pathogens, and its use is relevant
for the prophylaxis and treatment of infections in morbidly obese patients undergoing …

Background: Antimicrobial prophylaxis is a cornerstone to preventing surgical site infections
(SSIs). Ertapenem, a carbapenem antibiotic, is commonly used for surgical prophylaxis for …

Meropenem serves as a clinically important, broad-spectrum antibiotic. While meropenem is
commonly used in obese patients, its pharmacokinetics in this patient group is not well …

Background and Objectives A quantitative evaluation of the PK of meropenem, a broad-
spectrum β-lactam antibiotic, in plasma and interstitial space fluid (ISF) of subcutaneous …

Little is known of the effects of obesity on ertapenem drug disposition and
pharmacodynamics. Thirty healthy volunteers in three body mass index (BMI) groups (10 per …

Objectives: Ertapenem is FDA approved for the treatment of skin and skin-structure
infections (SSSI), but its in vivo penetration into the interstitial space of soft tissues is …

Background: There are only limited data on tissue kinetics of ertapenem in colorectal tissue
more than 3 h after administration of the drug. The purpose of this study was to assess the …

Objectives: Ertapenem, a class I carbapenem, is approved for the treatment of mild to severe
intraabdominal infections, but its in vivo concentrations in intraabdominal tissues are …

Despite a number of studies reporting that ertapenem pharmacokinetic parameters differ
considerably in obese patients from those in healthy volunteers, functions describing the …

Background The objective of this study was to determine the pharmacokinetics-
pharmacodynamics (PK/PD) of Ertapenem in extremely obese female patients (Body Mass …